Technology · platform overview

One capture session. 
Nine involuntary signal domains. 
A family of indices. 

Four live tests today: Balance, Eye Tracking, Cognitive, and rPPG heart rate concurrent. Two more, Simple Reaction Time and an Anti-Saccade prefrontal-inhibition probe, in integration this sprint. Additional biomarker domains on the roadmap.

Chronic Trace processes a short series of guided captures from a commodity camera-enabled device. Four live scored tests today: Balance, Eye Tracking, Cognitive, and rPPG heart rate captured concurrently with the eye-tracking video. Simple Reaction Time and an Anti-Saccade prefrontal- inhibition probe are wiring into the battery this sprint; additional biomarker domains are on the engineering roadmap. On devices whose front-facing sensor exposes an infrared stream, the platform additionally captures infrared-grade pupillometry. All live signal fuses through our Dispersion-Based Cognitive Intra-Individual Variability (d-CIIV) methodology into calibrated, indication-specific indices.

~30s · ~3 min
Per test · full session
04 / 06
Scored tests live · mapped
09
U.S. patents pending
The capture · moment by moment

The capture session, 
moment by moment. 

Four scored tests run in sequence: Balance, Eye Tracking, Cognitive, and rPPG heart rate extracted concurrently from the eye-tracking video. Simple Reaction Time and an Anti-Saccade prefrontal-inhibition probe are in integration this sprint. Additional biomarker domains are on the engineering pipeline; the labels below mark current status honestly.

01
Balance test (3-stance Romberg)
30 s · live
02
Eye tracking (pursuit + fixation + flash)
30 s · live
03
Heart rate via rPPG
concurrent · live
04
Cognitive test (TMT-A or Stroop)
30–60 s · live
05
Simple reaction time
30 s · integration
06
Anti-saccade probe (prefrontal inhibition)
60 s · integration
07
Pupillary autonomics
embedded · research mode
08
Bilateral asymmetry indices
post-process · research mode
09
Voice & speech acoustics
roadmap
10
Facial micro-expressions
roadmap
11
Retinal vascular imaging
roadmap · IR optics
d-CIIV · the scoring engine

Coherence, not performance. 

Healthy brain function exhibits tight coupling across pupillary, oculomotor, postural, and autonomic systems. Pathology — whether acute (concussion, stroke) or chronic (CTE, depression, prodromal psychosis, neurodegeneration) — manifests as dispersion: signals that drift apart from one another and from the individual's personal baseline.

The Dispersion-Based Cognitive Intra-Individual Variability framework converts that dispersion into a continuous, calibrated, longitudinally-comparable index. We measure how coherent the brain's systems remain over time, against the subject's own prior captures.

Manipulation resistance, by construction

The platform deliberately pairs voluntary task performance (the cognitive screens, the held stances, the simple reaction-time response) with involuntary biomarker channels (pupillary constriction to a light flash, saccadic latency, postural micro-corrections, autonomic measurements). The divergence between the two is itself a flagged signal. A subject attempting to under-perform a baseline degrades the voluntary channels while the involuntary channels remain physiologically anchored. That divergence is detectable. It is the architectural answer to the baseline-sandbagging and post-injury-concealment patterns that defeat every self-report screening tool in use today.

The clinical index family

One capture. 
Many indications. 

The launch indication is concussion, TBI, and CTE risk monitoring. The same capture session yields signal sufficient to extend across stroke triage, psychiatric severity grading, suicide-risk stratification, neurodegeneration and dementia risk, oncologic detection from ocular and retinal signs, infectious disease detection, and treatment-response monitoring.

LaunchExtended
01Launch

Concussion Likelihood Index (CLI)

Continuous 0 – 100 dispersion score; the launch indication.

02Launch

Individual Sensitivity Profile (ISP)

Per-subject calibration that lets the platform compare a person to themselves.

03Launch

Predictive Safe Activity Threshold (PSAT)

Return-to-play and operational-readiness signal.

04Launch

TBI Severity Classification

Acute and subacute traumatic brain injury grading.

05Launch

CTE Risk Index (CTE-RI)

Longitudinal monitoring of progressive neurodegenerative trends in living individuals.

06Extended

Stroke Likelihood / Severity / LVO probability

Pre-imaging triage. Time-of-onset estimation.

07Extended

Severity Indices — Depression, Anxiety, PTSD, Mania, Psychosis, Attention

Calibrated against PHQ-9, GAD-7, PCL-5, CAPS-5, YMRS, PANSS, and related reference instruments.

08Extended

Suicide Risk Index (SRI)

Designed to remain informative in patients motivated to conceal ideation.

09Extended

Treatment Response Probability Index

Serial monitoring during SSRI / SNRI, ketamine, esketamine, psilocybin-assisted therapy, TMS, ECT, and digital therapeutics.

Intellectual property

Nine filings. 
One interlocking portfolio. 

Not nine unrelated ideas. One method, protected in layers — the scoring foundation, the signals that feed it, and the indications it extends into. Each filing reinforces the others.

00
U.S. patents pending · Jan – May 2026
01FoundationalAutomated Inferential Prognostic SystemThe core engine — how dispersion across involuntary signals becomes one comparable number (the d-CIIV foundation).US 63/960,777Jan 2026
02ImpactFused Impact Telemetry and Neurological Coherence SystemTies real-world head-impact exposure to measured neurological coherence, tracked over time.US 64/050,597Apr 27, 2026
03OpticalMulti-Modal Retinal and Involuntary Signal SystemAdds the retinal vascular window and additional involuntary channels into the fused signal.US 64/052,047Apr 28, 2026
04StrokeStroke Detection, Triage, and Time-of-Onset EstimationPre-imaging stroke triage, including time-of-onset for wake-up and unknown-onset cases.US 64/055,576May 2, 2026
05BehavioralPsychiatric Severity, Treatment Response, Suicide RiskCalibrated psychiatric severity, treatment-response tracking, and a concealment-resistant suicide-risk signal.US 64/055,578May 2, 2026
06ComputeQuantum Computing System for Multi-Domain Brain-Health AssessmentForward-looking compute architecture for fusing every involuntary domain at scale.US 64/059,704May 7, 2026
07CognitiveNeurodegenerative Disease Detection and Dementia RiskAlzheimer's, MCI, and dementia risk from the same fused capture — the senior-care indication.US 64/075,301May 27, 2026
08OncologyOncologic Detection and Ocular Tumor MonitoringOcular and systemic-malignancy signs read from the retina — tumors, hematologic signs, paraneoplastic retinopathy.US 64/075,304May 27, 2026
09InfectiousInfectious Disease and Ocular Manifestation DetectionRetinal signatures of CMV, toxoplasmosis, malaria, TB, and syphilis — built for point-of-care and global health.US 64/075,307May 27, 2026

U.S. provisional patent applications filed. No claim is made that any application has been granted, nor that any claim herein is allowable. Patent prosecution is ongoing.

Open for discussion

For partners and researchers. 

The platform is under active validation. Pilot collaborations, cohort partnerships, and pharmaceutical-trial endpoints are open to discussion.